Sunday, December 30, 2012

Nobel winning 'Lady of the Cells' dies at 103

Fabio Campana / EPA file

Rita Levi Montalcini, who won the Nobel Prize for medicine in 1986 for her discovery of nerve growth factor, the first substance known to regulate the growth of cells, in a Feb. 23, 2007, file photo.

By Associated Press

ROME -- Rita Levi-Montalcini, a biologist who conducted underground research during World War II in defiance of Fascist persecution and went on to win a Nobel Prize for helping unlock the mysteries of the cell, died at her home on Sunday. She was 103 and had worked well into her final years.

Rome Mayor Gianni Alemanno, announcing her death in a statement, called it a great loss "for all of humanity." He praised her as someone who represented "civic conscience, culture and the spirit of research of our time."


Italy's so-called "Lady of the Cells," a Jew who lived through anti-Semitic discrimination and the Nazi invasion, became one of her country's leading scientists and shared the Nobel medicine prize in 1986 with American biochemist Stanley Cohen for their groundbreaking research carried out in the United States. The research increased the understanding of many conditions, including tumors, developmental malformations, and senile dementia.

Italy honored Levi-Montalcini in 2001 by making her a senator-for-life.

A petite woman with upswept white hair, she kept an intensive work schedule well into old age. "At 100, I have a mind that is superior ? thanks to experience ? than when I was 20," she said in 2009.

"A beacon of life is extinguished" with her death, said a niece, Piera Levi-Montalcini, who is a city councilwoman in Turin. The ANSA news agency quoted her as saying her aunt didn't suffer.

Levi-Montalcini was born April 22, 1909, to a Jewish family in the northern city of Turin. At age 20 she overcame her father's objections that women should not study and obtained a degree in medicine and surgery from Turin University in 1936.

She studied under top anatomist Giuseppe Levi, whom she often credited for her own success and for that of two fellow students and close friends, Salvador Luria and Renato Dulbecco, who also became Nobel Prize winners. Levi and Levi-Montalcini were not related.

After graduating, Levi-Montalcini began working as a research assistant in neurobiology but lost her job in 1938 when Italy's Fascist regime passed laws barring Jews from universities and major professions.

Her family decided to stay in Italy and, as World War II neared, Levi-Montalcini created a makeshift lab in her bedroom where she began studying the development of chicken embryos, which would later lead to her major discovery of mechanisms that regulate growth of cells and organs.

With eggs becoming a rarity due to the war, the young scientist biked around the countryside to buy them from farmers. She was soon joined in her secret research by Levi, her university mentor, who was also Jewish and who became her assistant.

"She worked in primitive conditions," Italian astrophysicist Margherita Hack told Sky TG24 TV in a tribute to her fellow scientist. "She is really someone to be admired."

The 1943 German invasion of Italy forced the Levi-Montalcini family to flee to Florence and live underground. After the Allies liberated the city, she worked as a doctor at a center for refugees.

In 1947 Levi-Montalcini was invited to the United States, where she remained for more than 20 years, which she called "the happiest and most productive" period of her life. She held dual Italian-U.S. citizenship.

During her research at Washington University in St. Louis, Missouri, she discovered nerve growth factor, the first substance known to regulate the growth of cells. She showed that when tumors from mice were transplanted to chicken embryos they induced rapid growth of the embryonic nervous system. She concluded that the tumor released a nerve growth-promoting factor that affected certain types of cells.

The research increased the understanding of many conditions, including tumors, developmental malformations, and senile dementia. It also led to the discovery by Cohen of another substance, epidermal growth factor, which stimulates the proliferation of epithelial cells.

Another Italian scientist, who worked for some 40 years with Levi-Montalcini, including in the United States, said the work the Nobel laureate did on nerve growth factor was continuing.

"Over the years, this field of investigation has become ever more important in the world of neuroscience," Pietro Calissano was quoted by ANSA as saying. "? We are working on a possible application in the treatment of Alzheimer's."

Levi-Montalcini returned to Italy to become the director of the laboratory of cell biology of the National Council of Scientific Research in Rome in 1969.

After retiring in the late 1970s, she continued to work as a guest professor and wrote several books to popularize science. She created the Levi-Montalcini Foundation to grant scholarships and promote educational programs worldwide, particularly for women in Africa.

She also became active in Parliament, especially between 2006 and 2008, when she and other life senators would cast their votes to back the thin majority of center-left Premier Romano Prodi.

Levi-Montalcini had no children and never married, fearing such ties would undercut her independence.

"I never had any hesitation or regrets in this sense," she said in a 2006 interview. "My life has been enriched by excellent human relations, work and interests. I have never felt lonely."

There was no immediate announcement of funeral or memorial services.

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Source: http://worldnews.nbcnews.com/_news/2012/12/30/16250863-italys-nobel-winning-lady-of-the-cells-dies-at-103?lite

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Saturday, December 29, 2012

A business plan? Start-ups need something else.

A business plan is great once entrepreneurs have tested the market and know what they're going to sell. But for starters, they really need to model their business.

By Dr. Jeffrey R. Cornwall,?Guest blogger / December 27, 2012

In this December file photo, 12-year-old entrepreneur William Zsigo enjoys one of his own chocolate confections as he poses for photos at his home in Haslett, Mich. Before entrepreneurs write up a business plan, they should model their business visually.

Greg DeRuiter/The State Journal/AP/File

Enlarge

When advising people about what they need to do as they get ready to launch a business, there are two distinct approaches recommended by experts.

Skip to next paragraph Dr. Jeffrey R. Cornwall

Jeff is the Jack C. Massey Chair in Entrepreneurship and Director of the Center for Entrepreneurship at Belmont University in Nashville, Tenn.

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The first, which has been the traditional approach, tells aspiring entrepreneurs that writing a business plan is the first critical step.

In business schools the business plan was the core of our entrepreneurship curriculum for decades. ?Writing a business plan that?s thickness is measured in inches is still a rite of passage in many top entrepreneurship programs.

However, there is a growing chorus of experts questioning why business plans get so much attention.? After all, most entrepreneurs will tell you that once the business gets going it can quickly look fundamentally different than described in their original business plan.

Deal reached to avert East coast port strike ... for now

(Reuters) - The union representing nearly 15,000 dockworkers at U.S. Atlantic and Gulf Coast seaports stretching from Boston to Corpus Christi, Texas, reached a tentative contract deal with shipping companies on Friday, averting a strike that threatened to wreak havoc on the U.S. economy.

The International Longshoremen's Association (ILA) and the U.S. Maritime Alliance clinched a deal in federally-mediated talks less than two days before a strike deadline set by the union to coincide with expiration of the contract on Sunday.

The threatened walkout would have brought container cargo operations to a halt at 15 ports along the Eastern seaboard and Gulf Coast, marking the first such work stoppage in 35 years. Friday's announcement came hours after the White House urged the parties to settle their dispute.

Under Friday's deal, the two sides agreed to extend the terms of their expiring labor pact for 30 more days while negotiators finalize details of their settlement, the Federal Mediation and Conciliation Service said in a statement.

The breakthrough came as the parties agreed "in principle" on the contentious issue of "container royalties," or bonus payments earned by ILA dockworkers based on the tonnage of cargo moved through their respective ports.

The new contract does not eliminate the royalty payments, as the shippers had demanded, according to Benny Holland, an executive vice president for the ILA.

"The royalty will stay intact. We have worked out a formula for it," he said in an interview. He did not elaborate and the shippers declined to comment. No further details were disclosed in the government's statement.

LONG-TERM AGREEMENT AWAITED

Established in 1960, the royalty payments to ILA workers are based on the tons of container cargo that move through a port. That tonnage has risen from 50 million tons in 1996 to 110 million tons last year, according to the alliance.

Total payments last year were $211 million, according to the USMX, or an average of $15,500 per worker.

The original idea of the royalty payments was to protect longshoremen from wage losses expected as a result of "containerization," in which more and more goods are packed in the now-familiar 20- and 40-foot long boxes. Those take less manpower to offload than the less-standardized containers they replaced.

The two sides also fought over the guaranteed eight-hour workday in the current contract as well as the seven-man "lashing gang." Lashing crews, or gangs, secure the cargo containers to the vessel using metal lashing rods to keep them from moving while the vessel is at sea. The maritime alliance wanted to eliminate each.

A new long-term agreement has an 80 percent chance of happening by January 28, Capital Alpha Partners analyst Loren Smith said in a research note.

The temporary agreement comes as labor forces felt emboldened by recent victories by other unions across the United States. At the same time, shipping companies and port operators have been using more automation, but have seen profits shrink.

The Baltic Dry index, which tracks the cost to ship materials overseas, is down 55 percent in the past year and currently trading at levels it has not seen in a decade.

(Additional reporting by Kevin Gray in Miami and Steve Gorman in Los Angeles, editing by Mary Milliken; desking by G Crosse)

Source: http://news.yahoo.com/mediator-says-deal-reached-avert-port-strike-now-171126727.html

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Friday, December 28, 2012

Couple Cite Great Need for Bowel Cancer Screening | Stuff.co.nz

A Christchurch couple who helped run a "pioneer" bowel-screening programme in the city four years ago are frustrated a national screening programme is not being rolled out sooner.

Derek and Lynn Anderson lost their 46-year-old daughter to cancer this year.

Lisa Mitchell died from ovarian cancer in June after the disease was not found until it had spread to her bowel.

The Andersons have advocated for a national bowel-screening programme for more than four years after helping their Rotary club run a pilot programme in Christchurch in 2008.

"One person dies every seven hours from bowel cancer," Derek Anderson said.

"It's 15 hours for breast cancer and 20 hours for road deaths, but you hear so much more about those. We thought we'd do something about this."

The programme involved GPs in Redcliffs and Riccarton sending letters to 800 patients aged between 55 and 65, with no previous history of bowel cancer, encouraging them to buy a self-testing kit from the clinic for $5.

He said 387 people bought kits.

Forty-six tests came back with a positive result, requiring a colonoscopy for further investigation.

"We found a few cancers," Anderson said.

The Government last year decided to start a pilot bowel-screening programme in the Waitemata district, but a national programme was still several years away.

The Ministry of Health-led pilot would run for four years, offering bowel screening to people aged 50 to 74 who were eligible for publicly funded healthcare.

Anderson said early intervention was the best way to save lives, and the screening programme needed to be rolled out across the country as soon as possible.

"I'd like the trial to be sped up, but I know it's a matter of finance."

There was also shortage of doctors who could perform colonoscopies and remove any growths found in the bowel, he said.

He called for more training for health professionals, including training nurses to perform the tests.

Lynne Anderson said she was pleased the pilot was happening, but wondered how many people would die while it was completed.

SIGN: Recognising bowel cancer Bowel cancer ? also known as colorectal cancer or colon cancer ? is any cancer affecting the colon and rectum. Most bowel cancers start as benign growths, called polyps, on the wall of the bowel. They do not produce symptoms and most are not pre-cancerous. Up to 75 per cent of bowel cancer is curable if caught early.

SYMPTOMS INCLUDE: Rectal bleeding without any obvious reason. Change in bowel habits, such as going to the toilet more often or having looser stools for several weeks. Abdominal pain. Lumps or mass in the stomach. Weight loss. Tiredness.

- ? Fairfax NZ News

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Source: http://www.stuff.co.nz/the-press/news/8127367/Couple-cite-need-for-screening

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Northeast Cobb Homes For Sale - Northeast Cobb, GA Patch

This week House Hunt presents eight homes for sale and listed at exactly the same price: $189,900. What can you buy for $189,900? Ranch homes, two-story homes, homes in great school districts, a swim/tennis community, private, fenced backyards, hardwoods, tile floors, 3-5 bedroom homes and upgrades galore! One home has two bedroom suites; another home has the master bedroom on the main with a sunroom overlooking a beautiful private in-ground pool. And this is the short list.

Click on a picture in the photo gallery to see a listing description. Click on an address listed below and get directly linked to AOL Real Estate for complete listing information. In addition to helpful home buying tips, maps and contact information for the listings you choose, you will also be to calculate a monthly mortgage payment, check your credit and get prequalified.?

3161 Oak Crest Traill, Marietta ?30062. $189,900. 4 Bedrooms ?3 Bathrooms ?3,392 Sq Ft. ? 0.41 Acre Lot.? John Wieland at his best! All spaces oversized including 3 walk-in-closets, fabulous fenced yard, 4 yr old roof, well maintained gormet kitchen ? a dream home for your family. Brokered By Re/Max Greater Atlanta-Cobb.

1653 Windcrest Drive Sw, Marietta ?30064. $189,900. 3 Bedrooms 3 Bathrooms. Beautiful total renovation. Tiled kitchen with new stainless appliances and countertops. Decor colors and plush newer Frieze carpet. New plumbing and lighting fixtures. Real hardwood floors. Large fenced backyard with patio/deck combo. Sought after schools. New high efficiency heating and A/C units. New exterior paint. Brokered By Keller Williams Realty Signature Partners.

3306 Timbersedge Drive, Marietta ?30064. $189,900. 3 Bedrooms ?2 Bathrooms. ?Easy living and "step free". Wonderful open floor plan w/family room open to dining room and kitchen allows for easy entertaining of family and friends. Smooth vaulted ceilings. Spacious master bedroom w/walk in closet, master bathroom w/large vanity & double sinks, linen closet. Bright sun porch or office. Cherry cabinets and upgraded kitchen counter tops. Tile floors in bathrooms and kitchen, 2 car garage w/extra storage. Great amenities. If you enjoy meeting people, there are many different scheduled activities in the clubhouse. Walk to shopping and restaurants. Brokered By Prudential Georgia Realty.

3119 Haverford Lane, Marietta ?30067. $189,900. Price Reduced. 4 Bedrooms ?2 Bathrooms. ?Next to Terrell Mill Park - 2.5 miles to I-75. Pristine 4-Sided Brick East Cobb Home. Finished terrace level with bedroom, full bath and family room with charming gas log free standing stove with its own thermostat & bookshelves. Refinished hardwood floors upstairs & under living room carpet - lovely kitchen: stainless oven & gas cooktop; Corian, custom cherry island-storage room or workshop. Swim/tennis, clubhouse: membership optional,? newer roof, fresh paint, new carpet, updated lighting,? security system, ?wonderful level backyard for play & gardening. Front Bermuda lawn with irrigation system. refrigerator, washer & dryer included. Brokered By Coldwell Banker Residential Brokerage.

1500 Brandon Drive Sw, Marietta? 30008. $189,900. 3 Bedrooms ?2 Bathrooms. ?Fabulous, updated ranch with a large yard for your next gathering. You will love to call this home, modern details in this ranch, no need for upgrades - move right in! Hardwood floors, expanded master bath with views to the backyard and an open floorplan so you can see everything from the kitchen. Enjoy the close proximity to the park as well. This home has a newer roof, water heater and furnace - all purchased in 2006. See this ready to move in ranch today! Brokered By Harry Norman Realtors.

951 Burnt Hickory Circle, Marietta ?30064. $189,900. 2 Bedrooms ?2 Bathrooms ?1,593 Sq Ft. Immaculate home in highly sought after neighborhood. New hardwood floors and new carpet, new interior paint, spacious living room with fireplace, dining area, fabulous sunroom, 2 nice bedroom suites with private baths and walk-in closets. Bright kitchen has a full range of appliances, breakfast bar and area, laundry room. Mint condition! Brokered By Harry Norman Realtors.

3925 Stanton Trail, Marietta ?30062. $189,900. 3 Bedrooms ?2 Bathrooms 1,597 Sq Ft? ?0.51 Acre Lot. ?Spacious ranch located in Providence Place. Great school district. This home offers a cozy stone fireplace in the family room, hardwood floors, separate dining, crisp white kitchen with a breakfast area, bonus room, large private yard with a relaxing patio, and a 2-car garage! Brokered By Rasmus Real Estate Group.

2853 Davis Road NE, Marietta, ?30062. $189,900. 3 Bedrooms ?2 Bathrooms ?Whether sitting out on the covered front porch or lounging by the private pool, this charming ranch offers the comforts of a cottage with the convenience and top schools of East Cobb. Renovated and updated, the light and bright kitchen opens to the dining/living room complete with a fireplace and 9 foot ceilings. The main level master suite has a beautiful sunroom with a view of the pool. Two additional bedrooms upstairs with a full bath. Plenty of storage. Brokered By Coldwell Banker Residential Brokerage.

Source: http://northeastcobb.patch.com/articles/house-hunt-what-can-you-buy-for-189900

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Sunday, December 23, 2012

Cash Loans - Usually Do Not Inconvenience on ... - JLPT Study

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You're able to do the investment recovery as the monetary overall health increases. A number of people don't want to borrow from relatives for a number of factors. Or some other motives associated with some form of culpability. Do not acknowledge the cash right until a contract is drafted. Many people are dealing with poverty and a lot of folks have acquire terrible hits on his or her credit scores. The common finance institutions will not likely cope with bad credit loans.
Right here is the easiest and quickest of all personal loans with bad credit since they only check your income having a pay stub plus they just involve that you've got a banking account. You can even get such type of mortgage online that has a piggy bank if you can't have a very bank account. Second, if you want to get a financial loan that provides you with more time to pay it back, then several neo standard financial institution for personal loans for poor credit. Fundamental essentials different types of loan providers that are not finance institutions and will not have as demanding of prerequisites being a loan company. They usually will require you to definitely have paid for on a little something in time for 6 weeks and as long as there is the income to guide he bank loan you will definitely get accepted. Previous, you should know that there are an alternative should you not want to deal with a payday loan and you also are unable to obtain a personal loan from another loan company.
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Source: http://www.jlpt-study.com/forum/cash-loans-usually-do-not-inconvenience-inadequate-finances

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Thursday, December 20, 2012

bush ulster: Children Keep Active In Science - Reference and ...

December 10th, 2012 by admin

At my high school reunion last week, I ran into an old friend. He and I had a biology class together when we were young. He told me that summer activities were a wonderful activity for youngsters, and that the best activities were science summer camps. He said that his children had attended some that were very enriching to their knowledge of science. He said that they were well worth the money that they cost, and they could meet others there.

Posted in Latest News About Education

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Source: http://www.forefrontcurriculum.com/latest-news-about-education/children-keep-active-in-science/

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PlayMemories Studio update for PS3 brings 4K image support, cloud features and more

PlayMemories Studio update for PS3 brings 4K image support, cloud features and more

Sony has been continually pushing its PlayMemories brand of apps across its hardware offerings, and this latest update falls at the feet of PlayStation 3 owners. It's PlayMemories Studio in particular, and a forthcoming patch that adds new functionality. The meat of the update centers around PlayMemories Online integration for added cloud-based photo and video sharing options, with slide shows. Other revisions include support for "improved" resolution of exported videos (up to 1080p), faster thumbnail display, more choices of background music, improved editing features and -- of particular interest to early adopters -- support for 4K photos with Bravia TVs. The version 2.0 release is slated for release "soon" but in the meantime head to the Sony Japan source link for a little more info in the interim.

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Via: AV WAtch

Source: PlayStation (twitter), Sony (Japan)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/REwaxLOgL7Q/

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UQ to lead national initiative to personalise breast cancer treatment

Professor Matt Trau

Professor Matt Trau

Researchers are working on a solution for a large number of breast cancer patients who do not respond to chemotherapy, using $5 million in new funding.

Funding from the National Breast Cancer Foundation (NBCF) will help with understanding the epigenetics of breast cancer biology, developing new diagnostics and moving towards specialised treatment methods.

Researchers hope their work will reduce the onset of advanced breast cancer, recurrence rates, stop disease progression and significantly increase survival rates.

Professor Matt Trau from the Australian Institute for Bioengineering and Nanotechnology at The University of Queensland, will be the project's lead chief investigator.

Researchers in nanotechnology, epigenetics, oncology and pathology from around Australia will share the new funding.

The research involves refining diagnostic tools to pinpoint markers for cancer sub-types and monitor patients during treatment.

The tools aim to improve and personalise treatment, which takes into account the sub-type of cancer, and allow for screening for the recurrence of the disease.

Prof Trau said the research would dramatically expand on the current breast cancer treatment regime, with recognition that the disease was not the same in all patients.

?It's not one disease. Recent research suggests it is at least nine different diseases, each of which requires a different treatment regime. In the clinic, we currently do not have a very good way of distinguishing between them effectively,? he said.

?Because of this problem, only a small percentage of cancer patients derive any benefit from chemotherapy. With the fusion of modern genetics, epigenetics and nanotechnology, we dream of being able to do much better.?

The new funding would allow for clinical trials, with researchers collecting biopsy and serum samples to determine how cancerous tumours responded to chemotherapy.

New technology will be used to evaluate epigenetic biomarkers during a patient's treatment, enabling researchers to track the tumours.

Researchers will also develop diagnostic devices and processes for breast cancer screening and move towards introducing them in certified clinical pathology labs.

The research will build on work in the past three years, which discovered epigenetic changes in the human body which pointed to the presence of breast cancer.

As well as UQ, the project will include Queensland Health, the Garvan Institute of Medical Research, the University of Newcastle, the Peter MacCallum Cancer Centre, Haematology and Oncology Clinics of Australasia, the Royal Brisbane and Women's Hospital and Holy Spirit Northside Hospital.

NBCF Director of Research Investment, Dr Alison Butt, said large-scale, collaborative research projects such as this were important in accelerating progress in breast cancer research.

?Bringing scientists together across multiple disciplines is critical to provide new perspectives on the current clinical challenges in breast cancer treatment,? she said.

?The NBCF is delighted to fund this exciting research program that has great potential to make a significant impact on those living with a diagnosis of breast cancer, and their families.?

Media: Erik de Wit, 0427 281 466, 3346 3962 or e.dewit@uq.edu.au

Source: http://www.uq.edu.au/news/index.html?article=25697

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Wednesday, December 19, 2012

Samsung lanza el Galaxy Grand, con Android 4.1.2 y doble SIM

Hoy, Samsung dio a luz a un nuevo tel?fono m?vil llamado Galaxy Grand, el que viene en dos variantes muy interesantes: una con dos ranuras para tarjetas SIM (GT-I9082) y otra con una sola de ?stas?(GT-I9080), siendo la ?nica diferencia notoria entre ambos.

En caracter?sticas comunes, el Galaxy Grand corre sistema operativo Android 4.1.2 (Jelly Bean) y?posee una pantalla de cinco pulgadas WVGA TFT LCD con resoluci?n de?800 x 480 pixeles,?procesador central doble n?cleo corriendo a 1,2GHz, 1GB de memoria RAM, 8GB de almacenamiento interno masivo y bater?a de 2100 mAh,?todo esto en un cuerpo de 9,6mm de espesor.

M?s detalles que estos no han sido revelados, faltando saber m?s detalles t?cnicos sobre su c?mara y otros aspectos, adem?s de su disponibilidad en pa?ses del mundo y m?s importante a?n, su precio, frente a lo cual estaremos muy atentos.

Link: Samsung unveils new 5-inch dual-SIM Galaxy Grand, with dual-core 1.2GHz processor and 8MP camera?(The Next Web)

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Source: http://www.wayerless.com/2012/12/samsung-lanza-el-galaxy-grand-con-android-4-1-2-y-doble-sim/

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Israel bars Haneen Zoabi from re-election

JERUSALEM (Reuters) -- Israel's electoral authority barred a Palestinian lawmaker from re-election on Wednesday, saying she had supported the nation's enemies by joining a protest ship that tried to break a naval blockade of Gaza.

Haneen Zoabi is expected to appeal to Israel's highest court which has overruled most previous efforts to disqualify Palestinian candidates as violations of free speech.

Israel's Central Elections Committee voted 19 to 9 with one abstention to block Zoabi's candidacy for the Jan. 22 general election, a committee spokesman said. Separate motions to disqualify two Palestinian political parties were defeated.

Zoabi was on board the Mavi Marmara ship which was boarded by Israeli troops as it approached waters off Gaza in May 2010 as part of an international flotilla challenging Israel's blockade on the enclave.

Nine Turkish citizens were killed, striking a huge blow to relations between the two countries.

The electoral committee disqualified Zoabi on two grounds: "negating Israel's existence as a Jewish state" and "support for an enemy state or terrorist organization engaged in armed conflict against Israel," spokesman Giora Pordes said.

Centrist and left-leaning Israeli lawmakers argued against disqualifying Zoabi.

"We cannot deny representation to people who disagree with us," said Nitzan Horowitz of the left-wing Meretz party.

Zoabi belongs to a tiny party in Israel's parliament that believes the country should not be defined as a Jewish state, which it sees as discriminatory toward the minority Palestinian population.

Most of the Palestinians who make up about 20 percent of the Israeli population are related to or descended from Palestinians who fled or were driven away in a 1948 war over Israel's establishment.

Zoabi has insisted she had no role in any of the violence on board the Mavi Marmara and had tried to mediate between the sides.

Source: http://www.maannews.net/eng/ViewDetails.aspx?ID=549558

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6th Circuit backs university in firing of employee for op-ed

Tuesday, December 18, 2012

CINCINNATI ? A former University of Toledo administrator lost an appeal yesterday over her firing for an opinion piece she wrote that a court said implied that gay people don?t deserve the same rights as black people.

A three-judge panel of the Cincinnati-based 6th U.S. Circuit Court of Appeals upheld a lower court?s ruling that dismissed a lawsuit filed by Crystal Dixon? against the university and its leaders.

In her lawsuit, Dixon argued that her firing over her April 2008 op-ed in the Toledo Free Press was a violation of her free-speech rights, because she wrote it as a private citizen, not on behalf of the university.

The 6th Circuit panel rejected that argument,saying that her public comments went against the very policies that the university wanted her to create and enforce as the associate vice president for human resources, and that the speech wasn?t protected.

In the op-ed, Dixon wrote that as a black woman, she takes ?great umbrage? at comparisons between gay rights and civil rights because gay people can choose a different lifestyle, while black people cannot change their skin color.

Dixon also argued to the university that she had hired at least two employees that were widely perceived to be gay.

The appeals panel wrote that Dixon?s op-ed showed that she does not think gay, bisexual and transgender students and employees at the university are entitled to civil-rights protections, even though the university expressly provides them.

Tags: Ohio, public comment, public concern, public employee speech, university

Source: http://feedproxy.google.com/~r/FirstAmendmentCenter/~3/Nye2hOxqT3s/6th-circuit-backs-university-in-firing-of-employee-for-op-ed

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Brad Paisley Performs in Cars Land for Disney Parks Christmas Day Parade


Brad Paisley Performs in Cars Land for Disney Parks Christmas Day Parade

Country superstar Brad Paisley recently taped a special performance at Disney California Adventure park for the Disney Parks Christmas Day Parade which airs on ABC December 25.

Brad is no stranger to Radiator Springs. You may remember he joined us for the grand opening of Cars Land in June, and of course, he sang two songs for the original soundtrack of the Disney?Pixar film ?Cars.? One of those songs, ?Behind the Clouds,? is the song you?ll see Brad perform Christmas Day on ABC. In the Eastern time zone, tune in from 10 a.m.-noon; in the Central, Mountain and Pacific time zones, tune in from 9-11 a.m. to catch all the fun from Walt Disney World and Disneyland Resorts!

Brad Paisley Performs in Cars Land for Disney Parks Christmas Day Parade

Keep an eye on the Disney Parks Blog for more updates on the 2012 Disney Parks Christmas Day Parade and join the conversation on Twitter with the hashtag #DisneyParade.

Tagged: DCA, DLR, Holidays

Filed: Celebrity Visits, Disney California Adventure Park, Disneyland Resort

Source: http://feedproxy.google.com/~r/DisneyParks/~3/cGBPxbwxWlE/

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The Catch-22 of Eyewitness ID

Police Officer Angel Ramirez questions a juvenile victim of an assault in 2010. The circumstances of the crime also come into play when considering the reliability of witness identification

Photo by Scott Olson/Getty Images.

Noris and Sherl Hilde were camping in the Umpqua National Forest in Oregon when a stranger with a large caliber hunting rifle approached their trailer in 2003. It was dark outside, around 10 p.m., and a shot rang out and hit Sherl while she was looking out the window. Noris called 911, but he was shot and killed while still on the phone. According to Sherl?s later testimony, the shooter entered the trailer, put a pillow over her face, and rummaged around unsuccessfully for keys to their truck. Sherl made it to a hospital, where surgery saved her life.?

In the aftermath of the shooting, the investigating detectives quickly focused on Samuel Lawson, who had been parked at the Hildes? campsite when they arrived that morning and moved his truck when they told him they had reserved the space. At trial, Sherl confidently identified Lawson, saying that she ?always knew it was him.? No blood, DNA, or other physical evidence linked him to the crime, though he did have a large caliber rifle with him earlier that week that he said was stolen from his unlocked truck before the Hilde shootings. Based largely on Sherl Hilde?s ID and testimony, a jury convicted Lawson in 2005 of aggravated murder and attempted murder. He was sentenced to life without the possibility of parole.

But Lawson never confessed to the crimes, and in retrospect, there was always reason to doubt Sherl?s eyewitness ID. She repeatedly told nurses at the hospital that she had never seen the shooter, which is why she was able to survive. She failed to pick the defendant out of at least three photo lineups she was shown in the days and weeks after the attack. She said while in the helicopter that took her to the hospital that the shooter was the man they had met earlier in the day?Lawson?but she also told paramedics that the helicopter pilot was the shooter and that she had not seen the shooter?s face. Detectives asked leading questions about the man she had met earlier in the day starting in their first interview with Hilde, and they told her that he was in custody before she ever identified him. Only after she was repeatedly shown pictures of Lawson alone and saw him at a pretrial hearing did Hilde pick him out of a photo lineup as the perpetrator. In other words, the police used classic suggestive tactics that can distort an eyewitness?s account.

Because of these questionable practices, the Oregon Supreme Court recently overturned Lawson?s conviction, sending the case back for a new trial. The court reviewed more than 2,000 studies of eyewitness ID procedures, which have turned up a multitude of problems. For starters, a study of 250 cases in which convictions were later overturned, as a result of DNA evidence exonerating the defendant, found false eyewitness IDs in 79 percent. Why so much unreliability? Sometimes police (consciously or subconsciously) encourage the witness to identify a suspect by asking leading questions and giving feedback to increase the witness? confidence when he or she gives the answer they?re looking for. Lineup procedure also matters?sequential lineups tend to be more accurate than simultaneous lineups because the witness tends to think, ?Is this the person I saw?? for each photo rather than ?Who looks the most like the person I saw?? Also, repeatedly viewing one suspect?s photo can confuse a witness into thinking he or she recognizes the suspect?s face from the crime.

The circumstances of the crime also come into play: the length of time the witness saw the suspect (shorter durations are generally less reliable) and the race of both the witness and the suspect (cross-racial IDS are also less reliable). Distance, light, and stress also can make a difference. Hilde saw the shooter who killed her husband and wounded her, if at all, in profile in a dimly lit trailer as she peeked from behind a pillow while suffering from a severe gunshot wound.

The upshot of the research is a conundrum for courts and the criminal justice system: We trust the memory of the person who saw the crime, but often we shouldn?t. Witness confidence is generally a poor indicator of the reliability of an ID. Juries, however, tend to believe witnesses who say they?re sure, even when they are told about the poor viewing conditions and suggestive police tactics.

All of this led the Oregon Supreme Court to develop a new standard for allowing an eyewitness identification into the evidence at trial. The court decreed that prosecutors will now bear the burden of showing that the eyewitness testimony they offer is reliable, instead of making the defense find evidence to show that it is not. Oregon is not the first state court to move in this direction. The New Jersey Supreme Court issued similar rules in 2011. The U.S. Supreme Court, on the other hand, recognized the problem of false eyewitness identifications last year while showing little interest in addressing it. It is up to the states, then, to follow New Jersey and Oregon in developing rules to ensure that the eyewitness ID juries hear are reliable. As for Lawson, the local district attorney will decide whether to retry him with or without Sherl Hilde?s testimony. One journalist following the case has argued that there isn?t enough evidence left to convict and Lawson should be allowed to go free.

Source: http://feeds.slate.com/click.phdo?i=b79aea61f7a526672fb6e53f0378984a

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Tuesday, December 18, 2012

Grenade attack at Pakistan army facility wounds 10

PESHAWAR, Pakistan (AP) ? Two men on a motorcycle hurled hand grenades at the main gate of an army recruiting center in northwestern Pakistan on Tuesday, wounding 10 people, police said.

The injured in the attack in the garrison town of Risalpur in Khyber Pakhtunkhwa province included civilians and security personnel, said senior police official, Ghulam Mohammed.

Mohammed told The Associated Press that the police have launched a manhunt to trace and arrest the attackers, he told The Associated Press.

No one immediately claimed responsibility for the attack, the latest in a string of assaults in recent days that illustrate the continued challenge Pakistan faces from militants despite military operations against the Pakistani Taliban and their supporters.

Tuesday's attack came a day after a car bomb exploded in a crowded market in Pakistan's northwestern town of Jamrud near the Afghan border, killing 17 people and wounding more than 40 others.

The Khyber Pakhtunkhwa province is located on the edge of Pakistan's tribal region, the main sanctuary for al-Qaida and Taliban in the country. The province has witnessed scores of attacks, most of them blamed on the Taliban.

Ten Taliban fighters armed with rockets and car bombs attacked the military section of an international airport in the northwestern city of Peshawar on Saturday night, killing four people and wounding over 40 others. Five of the militants were killed during the attack and the other five died Sunday after hours-long shootout with security forces.

Source: http://news.yahoo.com/grenade-attack-pakistan-army-facility-wounds-10-073719924.html

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Monday, December 17, 2012

Injured coral? Expect less sex

Injured coral? Expect less sex [ Back to EurekAlert! ] Public release date: 17-Dec-2012
[ | E-mail | Share Share ]

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo

Study finds that damaged coral colonies can take years to recover their reproductive prowess

BUFFALO, N.Y. Coral colonies that suffered tissue damage in The Bahamas were still producing low numbers of eggs four years after the injuries occurred, according to new research by University at Buffalo scientists. Tiny sperm-producing factories called spermaries were also in short supply.

The slow recovery was a surprise, said UB geology professor Howard Lasker, PhD, who led the study on the coral species Antillogorgia elisabethae.

"The really interesting finding was that four years later, these colonies were still displaying an effect," Lasker said. "They don't necessarily look damaged anymore, but it takes some time to get back to where they were in terms of reproduction."

"This research has broader repercussions," Lasker said. "When you start talking about damage to reefs from events like hurricanes, you might say that the coral survived, that it lost some tissue, but it's still reproducing. That's true, but we now know the corals are not quite as healthy as we thought."

The study appeared Dec. 1 in the Journal of Experimental Marine Biology and Ecology. Lasker's co-author was Christopher Page, a master's student in UB's Graduate Program in Evolution, Ecology and Behavior. Page, who has since graduated, is a biologist at the Mote Marine Laboratory in Florida.

The species that the researchers examined A. elisabethae, formerly known as Pseudopterogorgia elisabethae is a Caribbean gorgonian coral. The coral forms male and female colonies and, during reproduction, the females release eggs which remain on the colony's surface to be fertilized and develop into larvae.

To study the effect of tissue damage on sexual activity, Lasker and Page looked at egg and sperm production in A. elisabethae colonies near Cross Harbour, Abaco in The Bahamas.

In this region, workers harvest the coral, pruning branches from large, sexually mature colonies to obtain an anti-inflammatory chemical used in a skin care product.

Such harvests took place in 2002 and 2005. In 2009, Lasker and Page returned to the area before the annual spawning, which for A. elisabethae occurs in November and December. The researchers compared 24 colonies that had been cropped to 20 that had not, carefully dissecting 24 individual coral polyps from each of the 44 colonies to count the reproductive organs within.

What they found:

  • In cropped female colonies, roughly one in three polyps carried no eggs at all, compared with roughly one in six in uncropped colonies. The uncropped colonies also had more than double the number of polyps producing three or more eggs 120 polyps in all, compared with just 53 polyps in the cropped colonies.
  • More than three quarters of polyps in uncropped male colonies housed 11 or more spermaries, organs that produce sperm. In contrast, less than 60 percent of polyps in cropped colonies had 11 or more spermaries.

In most corals, sexual maturity is understood to be a product of colony size, as opposed to age. As a general rule, large corals reproduce. Small ones don't. The new research is the latest to support the notion that damaged corals may have lower fecundity because they divert resources away from reproduction and toward growth and injury repair, Lasker said.

"The mechanism controlling resource allocation is unknown, but regardless of the process the important implication of the finding is that populations that appear to have survived and to have recovered from disturbance events may produce fewer gametes than the size and number of colonies would suggest," Page and Lasker wrote in their study.

The researchers added that it's still unknown how changes in egg and spermary production impact long-term population growth.

###

The National Science Foundation and Mark Diamond Research Fund of the UB Graduate Student Association supported the study, which is titled, "Effects of tissue loss, age and size on fecundity in the octocoral Pseudopterogorgia elisabethae."


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?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Injured coral? Expect less sex [ Back to EurekAlert! ] Public release date: 17-Dec-2012
[ | E-mail | Share Share ]

Contact: Charlotte Hsu
chsu22@buffalo.edu
716-645-4655
University at Buffalo

Study finds that damaged coral colonies can take years to recover their reproductive prowess

BUFFALO, N.Y. Coral colonies that suffered tissue damage in The Bahamas were still producing low numbers of eggs four years after the injuries occurred, according to new research by University at Buffalo scientists. Tiny sperm-producing factories called spermaries were also in short supply.

The slow recovery was a surprise, said UB geology professor Howard Lasker, PhD, who led the study on the coral species Antillogorgia elisabethae.

"The really interesting finding was that four years later, these colonies were still displaying an effect," Lasker said. "They don't necessarily look damaged anymore, but it takes some time to get back to where they were in terms of reproduction."

"This research has broader repercussions," Lasker said. "When you start talking about damage to reefs from events like hurricanes, you might say that the coral survived, that it lost some tissue, but it's still reproducing. That's true, but we now know the corals are not quite as healthy as we thought."

The study appeared Dec. 1 in the Journal of Experimental Marine Biology and Ecology. Lasker's co-author was Christopher Page, a master's student in UB's Graduate Program in Evolution, Ecology and Behavior. Page, who has since graduated, is a biologist at the Mote Marine Laboratory in Florida.

The species that the researchers examined A. elisabethae, formerly known as Pseudopterogorgia elisabethae is a Caribbean gorgonian coral. The coral forms male and female colonies and, during reproduction, the females release eggs which remain on the colony's surface to be fertilized and develop into larvae.

To study the effect of tissue damage on sexual activity, Lasker and Page looked at egg and sperm production in A. elisabethae colonies near Cross Harbour, Abaco in The Bahamas.

In this region, workers harvest the coral, pruning branches from large, sexually mature colonies to obtain an anti-inflammatory chemical used in a skin care product.

Such harvests took place in 2002 and 2005. In 2009, Lasker and Page returned to the area before the annual spawning, which for A. elisabethae occurs in November and December. The researchers compared 24 colonies that had been cropped to 20 that had not, carefully dissecting 24 individual coral polyps from each of the 44 colonies to count the reproductive organs within.

What they found:

  • In cropped female colonies, roughly one in three polyps carried no eggs at all, compared with roughly one in six in uncropped colonies. The uncropped colonies also had more than double the number of polyps producing three or more eggs 120 polyps in all, compared with just 53 polyps in the cropped colonies.
  • More than three quarters of polyps in uncropped male colonies housed 11 or more spermaries, organs that produce sperm. In contrast, less than 60 percent of polyps in cropped colonies had 11 or more spermaries.

In most corals, sexual maturity is understood to be a product of colony size, as opposed to age. As a general rule, large corals reproduce. Small ones don't. The new research is the latest to support the notion that damaged corals may have lower fecundity because they divert resources away from reproduction and toward growth and injury repair, Lasker said.

"The mechanism controlling resource allocation is unknown, but regardless of the process the important implication of the finding is that populations that appear to have survived and to have recovered from disturbance events may produce fewer gametes than the size and number of colonies would suggest," Page and Lasker wrote in their study.

The researchers added that it's still unknown how changes in egg and spermary production impact long-term population growth.

###

The National Science Foundation and Mark Diamond Research Fund of the UB Graduate Student Association supported the study, which is titled, "Effects of tissue loss, age and size on fecundity in the octocoral Pseudopterogorgia elisabethae."


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-12/uab-ice121712.php

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Saturday, December 15, 2012

Evidence at suspected shooter?s home may point to motive, police say

Conn. State police spokesman Lt. Paul Vance at Saturday morning's news conference. (Jason Sickles/Yahoo News)

NEWTOWN, CT - Evidence recovered at gunman Adam Lanza's home may provide a motive for the massacre that left 26 dead at an elementary school, police said on Saturday.

State police spokesman Lt. Paul Vance declined to provide specifics about the evidence but said, "we're hopeful it will paint a complete picture."

Authorities say Lanza, 20, killed his mother Nancy Lanza, at their home?Friday morning before driving to Sandy Hook Elementary where he forced his way in to commit one of the worst mass shootings in U.S. history.

[Related: Follow the latest updates from our reporters in Newtown]

Armed with two semi-automatic pistols, Lanza rapidly sprayed bullets in hallways and classrooms. Twenty children, many of them kindergarteners, and six faculty members lost their lives. Lanza killed himself before police officers could reach him.

Lt. Vance said all the bodies were removed from the school overnight. A medical examiner is expected to release the names of the victims later today.

Police have assigned a trooper to support each victim's family in the days ahead. Vance asked reporters to respect the families' grief and privacy.

"This is an extremely heartbreaking thing for them to endure," Lt. Vance said.

Principal Dawn Hochsprung, 47, and first-grade teacher Vicki Soto, 27, have already been identified by family and friends as two of the slain staffers. Both are being heralded as heroes for putting themselves in harms way to protect children and colleagues.

It will likely take investigators two more days to process the school crime scene where it is believed Lanza fired as many as 100 rounds from his guns.

"It's going to be a slow, painstaking process," Lt. Vance said.

Source: http://news.yahoo.com/blogs/lookout/evidence-found-shooter-home-may-point-motive-police-155657663.html

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Damon on Douglas: He's 'a wonderful kisser'

Dave Allocca / AP file

Matt Damon and Michael Douglas.

By Gina Serpe, E! Online

Matt Damon is no stranger to real-life bromances (just ask Ben Affleck, John Krasinski, George Clooney, et al). But when it comes to the big screen, he's ditching his platonic pals and both getting naked and puckering up to Michael Douglas.

And he did so with gusto.

Check out Matt Damon's no-nonsense guide to holiday etiquette

Speaking to Playboy magazine about his upcoming role opposite Douglas in the upcoming Steven Soderbergh-directed HBO flick, Damon said his previous aversion to dropping trou in front of the cameras went out the window in his latest role.

"Normally I'd say no to nudity, but I just did a lot of it playing the longterm partner of Liberace, Scott Thorson, in 'Behind the Candelabra,'" he said. "I mean, it's tastefully done ... but the movie's not going to be for everyone.

"For one scene, I had to come out of the pool, go over to Michael Douglas, straddle him on a chaise lounge and start kissing him. It's not like I kiss him just once. We drew it up like a football plan."

Check out Matt and Michael work their magic in the Liberace flick

And as for his costar's lip-locking skills?

"Michael was a wonderful kisser."?

Evan Agostini / AP

But don't expect that kind of kiss-and-tell from his personal life.

See what Ben Affleck had to say about his bromance with Matt Damon

"The narrative about me kind of goes, 'He's a boring married guy,' which is great, because I don't get any of that other stuff like Brad Pitt and George Clooney do.... People think I'm kind of vanilla and they leave me alone to work, have an actual private life and be a husband and dad."

And a movie star, albeit one who seems like he's come to terms with what may be (though hopefully not) the end of his involvement in his most famous role.

Check out more Movies From the Future!

"You know what? They might have taken the 'Bourne' series out back and shot it in the head," he said when asked about continuing in the action franchise, which detoured this year with a Jeremy Renner-starring installment. "If that's the end of it, that's just the end of it. I hope not. I love the character and the three movies we did, so I'd love to figure out a way to do another one."?

That goes double for us.

Related content:

More in The Clicker:

Source: http://theclicker.today.com/_news/2012/12/14/15904393-matt-damon-on-nude-scenes-with-michael-douglas-hes-a-wonderful-kisser?lite

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Friday, December 14, 2012

Stem Group appoints new business sales manager | Business ...

9:32 am, December 13, 2012

Luke Latham

South west IT services company Stem Group has named Luke Latham as new business sales manager.

Latham has some 15 years? experience in the industry, having worked with a variety of customers from SMEs, schools and the public sector.

?Stem Group has grown significantly in the last few years and we?re delighted to be able to recruit local people,? said MD Stephen Tyrrell.

Source: http://www.businesscornwall.co.uk/news-by-industry/digital-industries/new-stem-recruit-123

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NASA moon-mapping mission to come to a crashing end

CAPE CANAVERAL, Florida | Thu Dec 13, 2012 8:43pm EST

CAPE CANAVERAL, Florida (Reuters) - NASA plans to crash a pair of small robotic science probes into the moon next week after a successful year-long mission to learn what lies beneath the lunar surface, officials said on Thursday.

The twin Gravity Recovery and Interior Laboratory, or GRAIL, spacecraft will make suicidal plunges on Monday into a mountain near the moon's north pole, a site selected to avoid the chance of hitting any of the Apollo or other lunar relics.

The impacts, which are not expected to be visible from Earth, will take place about 20 seconds apart at 5:28 p.m. EST (2228 GMT) on Monday.

"They're going to be completely blown apart," GRAIL project manager David Lehman, with NASA's Jet Propulsion Laboratory in Pasadena, California, told reporters on a conference call.

Almost out of fuel and currently flying just 7 miles above the lunar surface, the probes will make a final steering maneuver on Friday and shut down their science instruments in preparation for Monday's crash.

The two spacecraft, each about the size of a small washing machine, have been flying in close formation around the moon for nearly a year to map the lunar gravity.

Scientists precisely measure the distance between the two, a figure that slightly changes as they fly over denser regions of the moon. The gravitational pull of the additional mass causes first the leading probe and then the following one to speed up, altering the gap between them.

Gravity maps from the first part of the mission, collected between March and May 2012 when the spacecraft were about 34 miles above the lunar surface, revealed the moon has a shallower and much more fractured crust than expected - the result of asteroid and comet impacts billions of years ago.

"We know that the moon had been bombarded by impacts but what we found is just how broken up and fractured the crust of the moon is," said lead scientist Maria Zuber, with the Massachusetts Institute of Technology.

Similar bombardments happened on all the solid bodies of the inner solar system though the evidence on Earth has been erased by erosion, plate tectonics and other phenomena.

"With Mars, there's a questions about where did the water that we think was on the surface go," Zuber said. "These fractures provide a pathway deep inside the planet and it's very easy to envision now how a possible ocean on the surface could have found its way deep into the crust."

Scientists also discovered lava-filled subterranean cracks inside the moon, evidence that the body expanded early in its history.

In addition to planetary science, the gravity maps, along with detailed images of the lunar surface, should help engineers pick landing sites for future robotic and human expeditions to the moon, Zuber said.

"In my wildest dreams, I could not have imagined that this mission would have gone any better than it has," she said, adding that NASA will be getting $8 million or $9 million back from the mission's $471 million budget.

The spacecraft will hit the surface at about 3,760 miles per hour. No pictures are expected because the region will be dark at the time of impact, but a sister spacecraft circling the moon, NASA's Lunar Reconnaissance Orbiter, will attempt to survey the crash site.

"These are two small spacecraft with empty fuel tanks, so we're not expecting a flash that is visible from Earth," Zuber said.

(Editing by Kevin Gray and Mohammad Zargham)

Source: http://feeds.reuters.com/~r/reuters/scienceNews/~3/ngNTeAZZTHI/us-space-moon-crash-idUSBRE8BC1J720121214

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Researchers find new culprit in castration-resistant prostate cancer

Researchers find new culprit in castration-resistant prostate cancer [ Back to EurekAlert! ] Public release date: 13-Dec-2012
[ | E-mail | Share Share ]

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute

Previously unknown protein function could be a treatment target

BOSTONScientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs.

The researchers report in the Dec. 14 issue of Science that the molecular switch occurs in a protein, EZH2, which is increased in these tumors, termed castration-resistant prostate cancers (CRPC).

EZH2 is part of a protein complex that normally shuts off the expression of genes. But in CRPC cells, "It isn't working the way people had thought," said Myles Brown, MD, co-senior author of the report. Instead, EZH2 switches into a different mode, activating cell-growth genes -even in the absence of androgen hormones that spur the dangerous growth and spread of these cancers.

As a result, the researchers suggest that drugs designed to stifle this unexpected function of EZH2 might be effective as a new treatment strategy for CRPC tumors.

Brown's co-senior author is X. Shirley Liu, PhD; together they lead Dana-Farber's Center for Functional Cancer Epigenetics.

Most prostate tumors are fueled by male hormones, or androgens, which interact with a molecule called the androgen receptor in cancer cells. When the receptor receives androgen signals, it transmits orders to the cell's nucleus to divide and grow. Surgical castration or administering drugs that halt androgen production can control cancers that have spread outside the prostate gland.

However, these cancers often escape their need for androgens after a few years of treatment and become resistant. Brown said the tumor cells reprogram the androgen receptors so that they activate cell-growth genes despite the absence of hormone stimulation.

EZH2 is known as an "epigenetic regulator," meaning that it regulates the activity of genes without changing their DNA structure. Previously it was found that EZH2 levels are dramatically increased in late-stage castration resistant prostate cancer, Brown said, but researchers thought the protein was acting primarily to turn off gene activity which is its normal role.

Drugs aimed at blocking EZH2 activity are being tested in other cancers, where they are designed to block the protein's gene-suppressing role. However, they carry a risk of harmful side effects as a result. "But we found that isn't the important function of EZH2 in CRPC," Brown explained. "In these cancers, EZH2 works with the androgen receptor to turn on genes involved with cell growth." As a result, he proposes that inhibitors of EZH2 that avoid targeting its gene-repressor function might be a safe and effective strategy for use in castration-resistant prostate cancers.

Further, said Brown, the EZH2 protein itself is activated by a molecular signaling pathway known as PI3K, or PI3 kinase. Several PI3K inhibitors are in clinical trials at present, and Brown said that a combination of drugs to inhibit both that pathway and the EZH2 protein might be yet another way to attack the resistant prostate cancers.

###

Co-first authors of the report are Kexin Xu, PhD, and Zhenua Jeremy Wu, PhD, of Dana-Farber.

Support for the research was provided in part by the Prostate Cancer Foundation; the U.S. Department of Defense (PC100950); the National Cancer Institute (CA131945, CA89021, and CA90381); and the National Institutes of Health (CA166507, CA111803, CA090381, GM99409, CA85859 and CA097186).

Dana-Farber Cancer Institute is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute. It provides adult care with Brigham and Women's Hospital as Dana-Farber/Brigham and Women's Cancer Center, and it provides pediatric care with Children's Hospital Boston as Dana-Farber/Children's Hospital Cancer Center. Dana-Farber is the top-ranked cancer center in New England, according to U.S. News & World Report, and one of the largest recipients among independent hospitals of National Cancer Institute and National Institutes of Health grant funding. Follow Dana-Farber on Twitter: @dana-farber or Facebook: facebook.com/danafarbercancerinstitute.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Researchers find new culprit in castration-resistant prostate cancer [ Back to EurekAlert! ] Public release date: 13-Dec-2012
[ | E-mail | Share Share ]

Contact: Bill Schaller
william_schaller@dfci.harvard.edu
617-632-5357
Dana-Farber Cancer Institute

Previously unknown protein function could be a treatment target

BOSTONScientists at Dana-Farber Cancer Institute have discovered a molecular switch that enables advanced prostate cancers to spread without stimulation by male hormones, which normally are needed to spur the cancer's growth. They say the finding could lead to a new treatment for prostate cancers that are no longer controlled by hormone-blocking drugs.

The researchers report in the Dec. 14 issue of Science that the molecular switch occurs in a protein, EZH2, which is increased in these tumors, termed castration-resistant prostate cancers (CRPC).

EZH2 is part of a protein complex that normally shuts off the expression of genes. But in CRPC cells, "It isn't working the way people had thought," said Myles Brown, MD, co-senior author of the report. Instead, EZH2 switches into a different mode, activating cell-growth genes -even in the absence of androgen hormones that spur the dangerous growth and spread of these cancers.

As a result, the researchers suggest that drugs designed to stifle this unexpected function of EZH2 might be effective as a new treatment strategy for CRPC tumors.

Brown's co-senior author is X. Shirley Liu, PhD; together they lead Dana-Farber's Center for Functional Cancer Epigenetics.

Most prostate tumors are fueled by male hormones, or androgens, which interact with a molecule called the androgen receptor in cancer cells. When the receptor receives androgen signals, it transmits orders to the cell's nucleus to divide and grow. Surgical castration or administering drugs that halt androgen production can control cancers that have spread outside the prostate gland.

However, these cancers often escape their need for androgens after a few years of treatment and become resistant. Brown said the tumor cells reprogram the androgen receptors so that they activate cell-growth genes despite the absence of hormone stimulation.

EZH2 is known as an "epigenetic regulator," meaning that it regulates the activity of genes without changing their DNA structure. Previously it was found that EZH2 levels are dramatically increased in late-stage castration resistant prostate cancer, Brown said, but researchers thought the protein was acting primarily to turn off gene activity which is its normal role.

Drugs aimed at blocking EZH2 activity are being tested in other cancers, where they are designed to block the protein's gene-suppressing role. However, they carry a risk of harmful side effects as a result. "But we found that isn't the important function of EZH2 in CRPC," Brown explained. "In these cancers, EZH2 works with the androgen receptor to turn on genes involved with cell growth." As a result, he proposes that inhibitors of EZH2 that avoid targeting its gene-repressor function might be a safe and effective strategy for use in castration-resistant prostate cancers.

Further, said Brown, the EZH2 protein itself is activated by a molecular signaling pathway known as PI3K, or PI3 kinase. Several PI3K inhibitors are in clinical trials at present, and Brown said that a combination of drugs to inhibit both that pathway and the EZH2 protein might be yet another way to attack the resistant prostate cancers.

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Co-first authors of the report are Kexin Xu, PhD, and Zhenua Jeremy Wu, PhD, of Dana-Farber.

Support for the research was provided in part by the Prostate Cancer Foundation; the U.S. Department of Defense (PC100950); the National Cancer Institute (CA131945, CA89021, and CA90381); and the National Institutes of Health (CA166507, CA111803, CA090381, GM99409, CA85859 and CA097186).

Dana-Farber Cancer Institute is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute. It provides adult care with Brigham and Women's Hospital as Dana-Farber/Brigham and Women's Cancer Center, and it provides pediatric care with Children's Hospital Boston as Dana-Farber/Children's Hospital Cancer Center. Dana-Farber is the top-ranked cancer center in New England, according to U.S. News & World Report, and one of the largest recipients among independent hospitals of National Cancer Institute and National Institutes of Health grant funding. Follow Dana-Farber on Twitter: @dana-farber or Facebook: facebook.com/danafarbercancerinstitute.


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Source: http://www.eurekalert.org/pub_releases/2012-12/dci-rfn121312.php

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